A Mucosal IgA-Mediated Excretory Immune System In Vivo

A mucosal IgA-mediated excretory immune system in vivo.

The capacity of mucosal IgA Abs to serve as an excretory immune system in vivo was investigated. Mice expressing a transgenic TCR were immunized intragastrically with the cognate Ag to elicit a vigorous mucosal IgA Ab response. Soon after i.v. challenge, Ag was detected within the epithelial cells of the small intestinal crypts and to a lesser degree within the epithelial cells higher up the vi...

System In Vivo A Mucosal IgA-Mediated Excretory Immune

Recombinant secretory IgA for immune intervention against mucosal pathogens.

Mucosal epithelia of the human body, including the lining of the digestive, respiratory and urogenital tracts, comprises a vast surface permanently exposed to attack by exogenous pathogens. Protection of mucosal surfaces against colonization and possible invasion by pathogenic microorganisms is provided by a combination of constitutive non-specific substances such as mucus, lysozyme, lactoferri...

Inside the Mucosal Immune System

An intricate network of innate and immune cells and their derived mediators function in unison to protect us from toxic elements and infectious microbial diseases that are encountered in our environment. This vast network operates efficiently by use of a single cell epithelium in, for example, the gastrointestinal (GI) and upper respiratory (UR) tracts, fortified by adjoining cells and lymphoid...

IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.

The finding that ingestion of antigens results in the selection induction of IgA antibodies in external secretions suggests that antigen sensitizes Peyer's patch lymphoid cells, which migrate to mucosal sites and generate local secretory IgA (S-IgA) antibody responses. Evidence for a common mucosal immune system in humans has been scanty because of the difficulty in demonstrating migratory beha...